Genomic instability happens early in sporadic colorectal cancer
β Scribed by Dorothy Bonn
- Book ID
- 117291865
- Publisher
- The Lancet
- Year
- 2000
- Tongue
- English
- Weight
- 30 KB
- Volume
- 355
- Category
- Article
- ISSN
- 0140-6736
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Genomic instability plays a major role in cancer by facilitating tumor progression and tumor heterogeneity. Inter-simple sequence repeat (inter-SSR) PCR has been developed to provide a rapid and reproducible technique for quantitation of the major type of genomic instability observed in sporadic tum
Microsatellite instability in a subset of colorectal cancers from North America, Europe and Japan has been reported. We examined 88 colorectal cancers from Turkish patients. Five different microsatellite loci (I mono-and 4 dinucleotide repeat regions) were tested. Eight tumors displayed replication