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Genomic instability in colorectal cancers in Turkey

✍ Scribed by Tamer Yağci; Süha Göksel; Öner Doğan; Mehmet Ozturk; Nevzat Yurdusev

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
399 KB
Volume
68
Category
Article
ISSN
0020-7136

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✦ Synopsis

Microsatellite instability in a subset of colorectal cancers from North America, Europe and Japan has been reported. We examined 88 colorectal cancers from Turkish patients. Five different microsatellite loci (I mono-and 4 dinucleotide repeat regions) were tested. Eight tumors displayed replication errors (RERs) with at least 2 different markers. Right-sided tumors showed significantly higher frequency of microsatellite instability compared with left-sided tumors. The frequency of RER phenotype was slightly higher in tumors occurring in younger (<SO years old) than in older patients (I 3% vs. 8%). and there was no association between sex and genomic instability. The frequency of genomic instability in our study group was ! % , whereas the reported frequencies in tumors from other countries varied between 12% and 16%.

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