Genomic imprinting of the insulin-like growth factor 2 gene in sheep
β Scribed by Robert J. McLaren, Grant W. Montgomery
- Book ID
- 113034910
- Publisher
- Springer-Verlag
- Year
- 1999
- Tongue
- English
- Weight
- 95 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0938-8990
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Paternal allele-specific expression is identified for the insulinlike growth factor 2 (IGFZ) gene. Relaxation or loss of IGFZ imprinting, however, has been reported in several neoplasms. We studied the expression of IGFZ mRNA in 35 s q w m w s cancers of the esophagus and searched for the presence
## Background: Loss of imprinting (loi) of insulin-like growth factor-2 (igf-2) has been implicated in the pathogenesis of certain human cancers and tumor-predisposing overgrowth disorders, such as beckwith-wiedemann syndrome. in a previous study, the authors revealed that certain patients with chi
## BACKGROUND. Insulin-like growth factor-2 (IGF2) and H19 are reciprocally imprinted genes on chromosome 11; IGF2 is expressed paternally and H19 is expressed maternally. Loss of imprinting (LOI) at both H19 and IGF2 has been reported in seven fully informative adult testicular germ cell tumors (