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Genomic imprinting of insulin-like growth factor 2 (IGF-2) in chronic synovitis

✍ Scribed by B. Möller; G. Kerschbaumer; M. Komor; F. Kerschbaumer; O.G. Ottmann; D. Hoelzer; W.K. Hofmann

Book ID
116512195
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
275 KB
Volume
17
Category
Article
ISSN
1096-6374

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## Background: Loss of imprinting (loi) of insulin-like growth factor-2 (igf-2) has been implicated in the pathogenesis of certain human cancers and tumor-predisposing overgrowth disorders, such as beckwith-wiedemann syndrome. in a previous study, the authors revealed that certain patients with chi

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## BACKGROUND. Insulin-like growth factor-2 (IGF2) and H19 are reciprocally imprinted genes on chromosome 11; IGF2 is expressed paternally and H19 is expressed maternally. Loss of imprinting (LOI) at both H19 and IGF2 has been reported in seven fully informative adult testicular germ cell tumors (