## Abstract Comparative genomic hybridization (CGH) makes it possible to detect losses and gains of DNA sequences along all chromosomes in a tumor specimen based on the hybridization of differentially labeled tumor and normal DNA to normal human metaphase chromosomes. In this study, CGH analysis wa
Genome-wide survey of gains and losses of DNA sequences in primary prostate cancer by comparative genomic hybridization
β Scribed by T. Visakorpi; A. Kallioniemi; E. Hyytinen; J. Isola; M. Cher; R. Jensen; D. Pinkel; O.-P. Kallioniemi
- Book ID
- 119106268
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 107 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0165-4608
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Comparative genomic hybridization (CGH) was used to detect and map the regions of gain, high-level amplification, and loss of DNA sequences in 14 liposarcomas. Thirteen tumors showed DNA sequence copy number changes of one or more genomic regions (mean, six aberrationdtumor; range, 0-1 7). These abe
Comparative genomic hybridization (CGH) allows detection of chromosomal imbalances in whole genomes in a comprehensive manner. With this approach, ten cases of prostate cancer (seven primary tumors and three metastases) were analyzed. Frequent chromosomal gains detected by CGH involved chromosome ar
By means of comparative genomic hybridization (CGH), we screened 58 primary gastric cancers for changes in copy number of DNA sequences. We detected frequent losses on Ip32-33 (21%), 3p21-23 (22%), 5q14-22 (36%), 6q16 (26%), 9p21-24 (22%), 16q (21%), 17p13 (48%), 18q11-21(33%), and 19(40%). Gains we