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Genome-wide Association Study in a High-Risk Isolate for Multiple Sclerosis Reveals Associated Variants in STAT3 Gene

✍ Scribed by Eveliina Jakkula; Virpi Leppä; Anna-Maija Sulonen; Teppo Varilo; Suvi Kallio; Anu Kemppinen; Shaun Purcell; Keijo Koivisto; Pentti Tienari; Marja-Liisa Sumelahti; Irina Elovaara; Tuula Pirttilä; Mauri Reunanen; Arpo Aromaa; Annette Bang Oturai; Helle Bach Søndergaard; Hanne F. Harbo; Inger-Lise Mero; Stacey B. Gabriel; Daniel B. Mirel; Stephen L. Hauser; Ludwig Kappos; Chris Polman; Philip L. De Jager; David A. Hafler; Mark J. Daly; Aarno Palotie; Janna Saarela; Leena Peltonen


Book ID
113422776
Publisher
American Society of Human Genetics
Year
2010
Tongue
English
Weight
507 KB
Volume
86
Category
Article
ISSN
0002-9297

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## Abstract Genome‐wide association studies (GWAS) have been widely used to identify genetic effects on complex diseases or traits. Most currently used methods are based on separate single‐nucleotide polymorphism (SNP) analyses. Because this approach requires correction for multiple testing to avoi