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A Genome-wide Association Study Reveals that Variants within the HLA Region Are Associated with Risk for Nonobstructive Azoospermia

✍ Scribed by Han Zhao; Jianfeng Xu; Haobo Zhang; Jielin Sun; Yingpu Sun; Zhong Wang; Jiayin Liu; Qiang Ding; Shaoming Lu; Rong Shi; Li You; Yingying Qin; Xiaoming Zhao; Xiaoling Lin; Xiao Li; Junjie Feng; Li Wang; Jeffrey M. Trent; Chengyan Xu; Ying Gao; Bo Zhang; Xuan Gao; Jingmei Hu; Hong Chen; Guangyu Li; Junzhao Zhao; Shuhua Zou; Hong Jiang; Cuifang Hao; Yueran Zhao; Jinglong Ma; S. Lilly Zheng; Zi-Jiang Chen

Book ID
113423226
Publisher
American Society of Human Genetics
Year
2012
Tongue
English
Weight
857 KB
Volume
90
Category
Article
ISSN
0002-9297

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We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P ¼ 2.0 Â 10 -7 ) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further