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A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

✍ Scribed by van Heel, David A; Franke, Lude; Hunt, Karen A; Gwilliam, Rhian; Zhernakova, Alexandra; Inouye, Mike; Wapenaar, Martin C; Barnardo, Martin C N M; Bethel, Graeme; Holmes, Geoffrey K T

Book ID: 109919578
Publisher: Nature Publishing Group
Year: 2007
Tongue: English
Weight: 211 KB
Volume: 39
Category: Article
ISSN: 1061-4036
DOI: 10.1038/ng2058

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✦ Synopsis

We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P ¼ 2.0 Â 10 -7 ) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5¢ of IL21; metaanalysis P ¼ 1.3 Â 10 -14 , odds ratio ¼ 0.63), suggesting that genetic variation in this region predisposes to celiac disease.

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