Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families
✍ Scribed by Adamovic, S; Amundsen, S S; Lie, B A; Gudjónsdóttir, A H; Ascher, H; Ek, J; van Heel, D A; Nilsson, S; Sollid, L M; Torinsson Naluai, Å
- Book ID
- 109852790
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 93 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1466-4879
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We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P ¼ 2.0 Â 10 -7 ) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further
Objective. Autoimmune diseases often have susceptibility genes in common, indicating similar molecular mechanisms. Increasing evidence suggests that rs6822844 at the IL2-IL21 region is strongly associated with multiple autoimmune diseases in individuals of European descent. This study was undertaken