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Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease

✍ Scribed by Davila, Sonia; Wright, Victoria J; Khor, Chiea Chuen; Sim, Kar Seng; Binder, Alexander; Breunis, Willemijn B; Inwald, David; Nadel, Simon; Betts, Helen; Carrol, Enitan D

Book ID
109914642
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
801 KB
Volume
42
Category
Article
ISSN
1061-4036

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A genome-wide association study for celi
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
✍ van Heel, David A; Franke, Lude; Hunt, Karen A; Gwilliam, Rhian; Zhernakova, Ale πŸ“‚ Article πŸ“… 2007 πŸ› Nature Publishing Group 🌐 English βš– 211 KB

We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P ΒΌ 2.0 Γ‚ 10 -7 ) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further