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Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53-dependent pathway in human colon cancer cells

✍ Scribed by Yuan, Chun-Su

Book ID
120484307
Publisher
Spandidos Publications Ltd
Year
2013
Tongue
English
Weight
791 KB
Volume
43
Category
Article
ISSN
1019-6439

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## Abstract Methylxantine derivative, caffeine, is known to prevent the p53‐dependent apoptosis pathway via inhibition of ATM (ataxia telangiectasia mutated) kinase, which activates p53 by phosphorylation of the Ser‐15 residue. In contrast, it has been reported that caffeine induces p53‐mediated ap