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Isoliquiritigenin induces apoptosis and cell cycle arrest through p53-dependent pathway in Hep G2 cells

✍ Scribed by Ya-Ling Hsu; Po-Lin Kuo; Chun-Ching Lin

Book ID: 116717749
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 201 KB
Volume: 77
Category: Article
ISSN: 0024-3205
DOI: 10.1016/j.lfs.2004.09.047

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## Abstract Methylxantine derivative, caffeine, is known to prevent the p53‐dependent apoptosis pathway via inhibition of ATM (ataxia telangiectasia mutated) kinase, which activates p53 by phosphorylation of the Ser‐15 residue. In contrast, it has been reported that caffeine induces p53‐mediated ap