To the extent that cancer can be caused by somatic mutations) any understanding of carcinogenesis depends upon knowledge of the genes that are mutated. Two large classes of such genes have been discovered: (1) oncogenes, whose existence was revealed by the study of the animal retroviruses, and (2) a
β¦ LIBER β¦
Genetics of human cancer
β Scribed by Alfred Knudson
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 96 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0360-3016
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## Abstract Cancer is a genetic disease of somatic cells. Tumor karyotypes are rarely normal, and most show multiple abnormalities of both number and structure. The first direct evidence for this concept of cancer came from studies of tumorβspecific translocations in leukemias and lymphomas, reveal
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