Genetically distinct components of copper transport in yeast
β Scribed by Val Culotta; Xiu Fen Liu
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 96 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0162-0134
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π SIMILAR VOLUMES
Copper is essential for life processes as cofactor for many vital cuproenzymes, yet it is extremely toxic in excess. Efficient mechanisms have been developed to recruit and deliver copper to enzymes and for excretion of surplus metal. Imbalance of copper homeostasis is manifested in two human illnes
According to the "energy recycling model" (Michels et al., 1979; Otto et al., 1980; Ten Brink and Konings, 1980) carrier-mediated effiux of metabolic end-products can generate an electrochemical proton gradient across the cytoplasmic membrane and therefore contributes to the energy generation of bac
Several complementary approaches have been fruitful in the study of transport from the ER to the Golgi complex in yeast. Mutational analysis has led to the identification of genes required for this process, many of which are now being studied at the molecular and biochemical level. In the case of SE
Mter a short introduction on the historical background of the development of Saccharomyces cere&iae as a model eukaryote, a review is given on the present state of genetics and molecular biology of copper resistance in 5. cereviaiae. The gene CUPl encodes a protein (copper metallothionein) of a mole