The molecular genetics of copper resistance in Saccharomyces cerevisiae — a paradigm for non-conventional yeasts
✍ Scribed by Prof. Dr. Seymour Fogel; Juliet W. Welch; Daniel H. Maloney
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 935 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0233-111X
No coin nor oath required. For personal study only.
✦ Synopsis
Mter a short introduction on the historical background of the development of Saccharomyces cere&iae as a model eukaryote, a review is given on the present state of genetics and molecular biology of copper resistance in 5. cereviaiae. The gene CUPl encodes a protein (copper metallothionein) of a molecular weight of 6570 dalton. The synthesis of this copper chelatin is induced by copper and is regulated a t the level of transcription.
Copper resistance (CUP') is correlated with amplification of CUPl and resulted in a higher copy number of this gene on chromosome VIII. Spontaneous meiotic alterations of the gene copy number have been studied.