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Genetic variation at a single locus and age of onset for Alzheimer's disease

✍ Scribed by Michael W. Lutz; Donna G. Crenshaw; Ann M. Saunders; Allen D. Roses

Book ID: 118465744
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 596 KB
Volume: 6
Category: Article
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2010.01.011

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## Abstract The __MAPT__ gene that encodes Tau is located on chromosome 17q21, in a region, which has evolved to form two major haplotypes, H1 and H2. There is strong evidence that the H1 haplotype, and a sub‐haplotype (H1C), are overrepresented and associated with increased risk for the sporadic t