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P3-235: Genetic contributions to age-at-onset variation in early-onset Alzheimer's disease in Caribbean Hispanic families

✍ Scribed by Lee, Joseph H.; Rogaeva, Ekaterina; Park, Naeun; Santana, Vincent; Williamson, Jennifer; Bodnar, Katharine; Jimenez-Velazquez, Ivonne; Medrano, Martin; St. George-Hyslop, Peter; Mayeux, Richard

Book ID: 123384106
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 56 KB
Volume: 4
Category: Article
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2008.05.1802

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## Abstract We performed linkage analysis for age at onset (AAO) in the total Alzheimer's disease (AD) NIMH sample (N = 437 families). Families were subset as late‐onset (320 families, AAO ≥65) and early/mixed (117 families, at least 1 member with 50< AAO <65). Treating AAO as a censored trait, we