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Age of onset and genetic predisposition in familial Alzheimer's disease

✍ Scribed by Crawford, F; Bennett, C; Osborne, A; Diaz, P; Mullan, M


Book ID
124111866
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
179 KB
Volume
15
Category
Article
ISSN
0197-4580

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## Abstract The effect of the apolipoprotein E (APOE) Ο΅4 allele on age of onset was analyzed in two groups of families with early‐onset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) early‐onset non‐VG families showing evidence of linkage