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Genetic Variants of the Organic Cation Transporter 2 Influence the Disposition of Metformin

โœ Scribed by Song, IS; Shin, HJ; Shim, EJ; Jung, IS; Kim, WY; Shon, JH; Shin, JG

Book ID
109845642
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
176 KB
Volume
84
Category
Article
ISSN
0009-9236

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Transport of drugs in the kidney by the
Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants
โœ Tomoe Fujita; Thomas J. Urban; Maya K. Leabman; Kazumi Fujita; Kathleen M. Giaco ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 284 KB

The human organic cation transporter 2 (OCT2, SLC22A2) is a multispecific transporter of organic cations, including many clinically used drugs. OCT2 is primarily responsible for the uptake of organic cations across the basolateral membrane of renal tubular epithelial cells and is considered a major