The human organic cation transporter 2 (OCT2, SLC22A2) is a multispecific transporter of organic cations, including many clinically used drugs. OCT2 is primarily responsible for the uptake of organic cations across the basolateral membrane of renal tubular epithelial cells and is considered a major
✦ LIBER ✦
Genetic variants of organic cation transporter 1 (OCT1) and OCT2 significantly reduce lamivudine uptake
✍ Scribed by Min-Koo Choi; Im-Sook Song
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 271 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.1783
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## Abstract Various possible pathways for the uptake of cationic alkylamine platinum(II) complexes into the MCF‐7 breast cancer cells were studied with di[meso‐1,2‐bis(4‐fluorophenyl)ethylenediamine]di[sulfinylbis(methane)‐S][μ‐1,6‐diaminohexaneN:N′]diplatinum(II) disulfate (m‐4F‐PtDMSO‐DAH) as an