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Genetic variants in TP53 and MDM2 associated with male infertility in Chinese population

✍ Scribed by Huang, Cong; Liu, Wei; Ji, Gui-Xiang; Gu, Ai-Hua; Qu, Jian-Hua; Song, Ling; Wang, Xin-Ru

Book ID: 120022696
Publisher: Nature Publishing Group
Year: 2012
Tongue: English
Weight: 157 KB
Volume: 14
Category: Article
ISSN: 1008-682X
DOI: 10.1038/aja.2012.39

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## Abstract Overexpression of MDM2 may attenuate the P53 stress response pathway through direct blocking of P53 transcriptional activity and mediating P53 degradation. Two promoter polymorphisms (one is a T to G substitution at the intronic P53‐response promoter, and the other is a 40‐bp insertion/