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Genetic studies on human thyroxine-binding globulin (TBG)

✍ Scribed by C. Luckenbach; J. Kömpf; H. Ritter

Book ID
118287258
Publisher
Springer
Year
1990
Tongue
English
Weight
356 KB
Volume
84
Category
Article
ISSN
0340-6717

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Sequence of the variant thyroxine-bindin
Sequence of the variant thyroxine-binding globulin (TBG) in a Montreal family with partial TBG deficiency
✍ Onno E. Janssen; Kyoko Takeda; Samuel Refetoff 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 446 KB

The variant thyroxine-binding globulin in a family from Montreal (TBG-M) has a reduced affinity for thyroxine, shows a slight cathodal shift on isoelectric focusing, and has an increased susceptibility to inactivation by heat and acid. We present the molecular basis for TBG-M, deduced by sequencing