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The structure of the human thyroxine binding globulin (TBG) gene

✍ Scribed by Mohammed T. Akbari; Abdul Kapadi; Malcolm J. Farmer; Nicholas J.S. Fitch; Karen P. McCann; Soheila Kordestani; Irwin L. Flink; Michael C. Sheppard; David B. Ramsden

Book ID
113262753
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
818 KB
Volume
1216
Category
Article
ISSN
0167-4781

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Sequence of the variant thyroxine-bindin
Sequence of the variant thyroxine-binding globulin (TBG) in a Montreal family with partial TBG deficiency
✍ Onno E. Janssen; Kyoko Takeda; Samuel Refetoff πŸ“‚ Article πŸ“… 1991 πŸ› Springer 🌐 English βš– 446 KB

The variant thyroxine-binding globulin in a family from Montreal (TBG-M) has a reduced affinity for thyroxine, shows a slight cathodal shift on isoelectric focusing, and has an increased susceptibility to inactivation by heat and acid. We present the molecular basis for TBG-M, deduced by sequencing