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Complete thyroxine-binding globulin (TBG) deficiency caused by a single nucleotide deletion in the TBG gene

โœ Scribed by Peizhi Li; Onno E. Janssen; Kyoko Takeda; Richard H. Bertenshaw; Samuel Refetoff


Book ID
116030440
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
835 KB
Volume
40
Category
Article
ISSN
1532-8600

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Sequence of the variant thyroxine-bindin
โœ Onno E. Janssen; Kyoko Takeda; Samuel Refetoff ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Springer ๐ŸŒ English โš– 446 KB

The variant thyroxine-binding globulin in a family from Montreal (TBG-M) has a reduced affinity for thyroxine, shows a slight cathodal shift on isoelectric focusing, and has an increased susceptibility to inactivation by heat and acid. We present the molecular basis for TBG-M, deduced by sequencing