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Genetic studies in Alzheimer's disease with an NACP/α-synuclein polymorphism

✍ Scribed by Yu Xia; H. A. Rohan de Silva; Barbara L. Rosi; Larry H. Yamaoka; Jacqueline B. Rimmler; Margaret A. Pericak-Vance; Allen D. Roses; Xiaohua Chen; Eliezer Masliah; Richard Deteresa; Akihiko Iwai; Mary Sundsmo; Ronald G. Thomas; C. Richard Hofstetter; Ethan Gregory; Lawrence A. Hansen; Robert Katzman; Leon J. Thal; Tsunao Saitoh

Book ID
102709254
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
875 KB
Volume
40
Category
Article
ISSN
0364-5134

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✦ Synopsis

The non-AD component of Alzheimer's disease amyloid (NAC) is copurified with amyloid from the brain tissue of Alzheimer's disease victims and is immunohistochemically localized to amyloid fibrils. NAC is a hydrophobic peptide fragment from the NAC precursor protein (NACP/a-synuclein) that is localized to presynaptic terminals. We used a polymorphic dinucleotide repeat sequence in a genomic clone of NACP for genetic association and linkage studies. Screening of Alzheimer's disease families failed to establish linkage between NACP and Alzheimer's disease. Nevertheless, one of the NACP polymorphisms (NACP allele 2) was shown to have significant association with healthy elderly control individuals with apolipoprotein E risk. This may indicate a possible protective function of the allele.

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Failure to replicate a protective effect
Failure to replicate a protective effect of allele 2 of NACP/α-synuclein polymorphism in Alzheimer's disease: An association study
✍ Nathan E. Hellman; Elizabeth A. Grant; Dr. Alison M. Goate 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 390 KB 👁 1 views

## Abstract Recently, a dinucleotide repeat polymorphism was identified in the promoter of the nonamyloid component of plaques (NACP) gene, and it was shown that the NACP allele 2 was significantly associated with healthy elderly control individuals with at least one apolipoprotein E ε4 allele, sug