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Failure to replicate a protective effect of allele 2 of NACP/α-synuclein polymorphism in Alzheimer's disease: An association study

✍ Scribed by Nathan E. Hellman; Elizabeth A. Grant; Dr. Alison M. Goate

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 390 KB
Volume: 44
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.410440223

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✦ Synopsis

Abstract

Recently, a dinucleotide repeat polymorphism was identified in the promoter of the nonamyloid component of plaques (NACP) gene, and it was shown that the NACP allele 2 was significantly associated with healthy elderly control individuals with at least one apolipoprotein E ε4 allele, suggesting a protective role for this allele in Alzheimer's disease. We genotyped the same NACP polymorphism in a comparable number of individuals diagnosed with dementia of the Alzheimer's type and in healthy, elderly controls. In our analysis, however, no protective effect for NACP allele 2, or any of the other NACP alleles, was observed.

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