Antibodies to α-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease

A panel of epitope-specific antibodies d

A panel of epitope-specific antibodies detects protein domains distributed throughout human α-synuclein in lewy bodies of Parkinson's disease

✍ Benoit I. Giasson; Ross Jakes; Michel Goedert; John E. Duda; Susan Leight; John 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 192 KB

To facilitate studies of the normal biology of ␣-synuclein, a member of a family of neuronal proteins of unknown function, and to elucidate the role of ␣-synuclein pathologies in neurodegenerative diseases, we generated and characterized a panel of anti-synuclein antibodies. Here we demonstrate that