𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations

✍ Scribed by Brachmann, Rainer K.; Yu, Kexin; Eby, Yolanda; Pavletich, Nikola P.; Boeke, Jef D.

Book ID
111745906
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
722 KB
Volume
17
Category
Article
ISSN
0261-4189

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

The screening of the second-site suppres
The screening of the second-site suppressor mutations of the common p53 mutants
✍ Kazunori Otsuka; Shunsuke Kato; Yuichi Kakudo; Satsuki Mashiko; Hiroyuki Shibata πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 French βš– 372 KB

## Abstract Second‐site suppressor (SSS) mutations in p53 found by random mutagenesis have shown to restore the inactivated function of some tumor‐derived p53. To screen novel SSS mutations against common mutant p53s, intragenic second‐site (SS) mutations were introduced into mutant p53 cDNA in a c