The screening of the second-site suppres
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Kazunori Otsuka; Shunsuke Kato; Yuichi Kakudo; Satsuki Mashiko; Hiroyuki Shibata
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Article
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2007
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John Wiley and Sons
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French
β 372 KB
## Abstract Secondβsite suppressor (SSS) mutations in p53 found by random mutagenesis have shown to restore the inactivated function of some tumorβderived p53. To screen novel SSS mutations against common mutant p53s, intragenic secondβsite (SS) mutations were introduced into mutant p53 cDNA in a c