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SELECTIVE DETECTION OF INACTIVATING MUTATIONS OF THE TUMOR SUPPRESSOR GENE p53 IN BLADDER TUMORS

✍ Scribed by PFISTER, CHRISTIAN; FLAMAN, JEAN MICHEL; MARTIN, COSETTE; GRISE, PHILIPPE; FREBOURG, THIERRY


Book ID
120190431
Publisher
Lippincott Williams and Wilkins
Year
1999
Tongue
English
Weight
390 KB
Volume
161
Category
Article
ISSN
0022-5347

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Transgenic mice deficient for the p53 gene were reported to frequently develop angiosarcoma (AS), suggesting that alterations in the gene are associated with tumorigenesis of AS. However, little is known about genetic changes, including p53 gene alterations, in human AS because of its rarity. We ana