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Genetic segregation of multiple sclerosis and histocompatibility (HLA) haplotypes

✍ Scribed by M. Alter; J. Quevedo

Publisher
Springer
Year
1979
Tongue
English
Weight
383 KB
Volume
222
Category
Article
ISSN
0340-5354

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✦ Synopsis

The possibility that a gene determining susceptibility to multiple sclerosis (MSS) may be closely linked to the major histocompatibility locus (HLA) is suggested by observation of a loose association between multiple sclerosis (MS) and certain HLA determinants. In the present study, the possible association was analyzed by studying the segregation of MS and the HLA haplotypes in families with more than one case of MS. Analysis of 48 published families revealed that the haplotype shared by those with MS within the family was also shared by those without clinical signs of MS at close to the 50% frequency expected by chance. Thus, we were unable to demonstrate that MS is associated with one HLA defined parental haplotype. We discussed reasons for this apparent failure to demonstrate existence of an MSS gene using available multiplex MS families.

πŸ“œ SIMILAR VOLUMES

Family studies in multiple sclerosis: HL
Family studies in multiple sclerosis: HLA haplotypes of affected sib-pairs
✍ H. J. Mayer-Rienecker; S. Wegener; B. Hitzschke πŸ“‚ Article πŸ“… 1984 πŸ› Springer-Verlag 🌐 English βš– 224 KB

The occurrence of multiple sclerosis (MS) in several members of families has been observed in 4.8% of 105 MS patients from a limited epidemiological area of Rostock. Typing of the HLA antigens in 4 affected sib-pairs showed two identical HLA haplotypes in 3 of the pairs: 1 pair shared one haplotype.