Combined segregation and linkage analysis of multiple sclerosis
โ Scribed by S. L. Sherman; R. W. C. Haile; C. J. MacLean; S. Yee
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 295 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
A combined segregation, linkage, and association analysis using the program COMBIN was performed on the simulated pedigree data prepared for the Second Genetic Analysis Workshop. The model used in COMBIN is described and the presented results illustrate its effectiveness in the analysis of such data
We conducted linkage analyses of immunoglobulin G heavy chain marker (Gm) phenotypes and multiple sclerosis (MS) in 30 families, each having at least two first-degree relatives with definite/probable MS. These families yielded positive evidence for linkage to human leukocyte antigen (HLA) loci in pr