Although multipoint linkage data are becoming quite common, economical and efficient methods for presenting these data are not yet in use. Tables giving the full likelihood function would be very voluminous, whereas reduction to standard lods destroys part of the information. We suggest a special lo
Conditional linkage analysis of multiple sclerosis data
โ Scribed by Neil Risch
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 331 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
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We conducted linkage analyses of immunoglobulin G heavy chain marker (Gm) phenotypes and multiple sclerosis (MS) in 30 families, each having at least two first-degree relatives with definite/probable MS. These families yielded positive evidence for linkage to human leukocyte antigen (HLA) loci in pr
The problem of compact, fully efficient representation of multilocus data has not yet been solved. Lod scores can be used to map multilocus data, but because of certain statistical problems, this method loses some information. However, simulation studies show that for distances less than 10 or 20 cM