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Genetic screening for LRRK2 gene G2019S mutation in Parkinson's disease patients from Southern Italy

✍ Scribed by Anna De Rosa; Chiara Criscuolo; Pietro Mancini; Marina De Martino; Ilaria Anna Giordano; Sabina Pappatà; Alessandro Filla; Giuseppe De Michele

Book ID
116820546
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
259 KB
Volume
15
Category
Article
ISSN
1353-8020

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To evaluate the frequency of the LRRK2 G2019S mutation in Italy, we tested 1,072 probands with Parkinson's disease (PD; 822 sporadic and 250 familial): 20 patients (1.9%) carried the G2019S mutation, 11 patients (1.3%) were sporadic, and 9 (4.3%) had a positive family history. Considering only proba