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Genetic predisposition to cancer — insights from population genetics

✍ Scribed by Frank, Steven A.

Book ID: 109951970
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 309 KB
Volume: 5
Category: Article
ISSN: 1471-0056
DOI: 10.1038/nrg1450

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Two classes of inherited susceptibility genes may be considered in the etiology of breast and other common cancers. First, genes have been identified that confer a high degree of breast cancer (BC) risk, usually associated with hereditary syndromes, but disease-associated germline variants in these