Genetic polymorphisms of glutathione S-transferase genesGSTP1,GSTM1, andGSTT1and risk of esophageal and gastric cardia cancers
β Scribed by Kazem Zendehdel; Shahram Bahmanyar; Shane McCarthy; Olof Nyren; Bjorn Andersson; Weimin Ye
- Publisher
- Springer Netherlands
- Year
- 2009
- Tongue
- English
- Weight
- 199 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0957-5243
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Glutathione S-transferases (GSTs) belong to a superfamily of detoxification enzymes that provide critical defences against a large variety of chemical carcinogens and environmental toxicants. GSTs are present in most epithelial tissues of the human gastrointestinal tract. We investigated association
Several polymorphic glutathione S-transferase enzymes are involved in the detoxification of active metabolites of many potential carcinogens from tobacco smoke and may therefore be important in modulating susceptibility to smoking-related cancers. As part of a hospital-based case-control study perfo