Several polymorphic glutathione S-transferase enzymes are involved in the detoxification of active metabolites of many potential carcinogens from tobacco smoke and may therefore be important in modulating susceptibility to smoking-related cancers. As part of a hospital-based case-control study perfo
Polymorphisms of glutathione-S-transferase genes (GSTP1, GSTM1 and GSTT1) and prostate-cancer risk
โ Scribed by Andrea Gsur; Gerald Haidinger; Sonja Hinteregger; Gabriele Bernhofer; Georg Schatzl; Stephan Madersbacher; Michael Marberger; Christian Vutuc; Michael Micksche
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- French
- Weight
- 57 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Glutathione S-transferases (GSTs) belong to a superfamily of detoxification enzymes that provide critical defences against a large variety of chemical carcinogens and environmental toxicants. GSTs are present in most epithelial tissues of the human gastrointestinal tract. We investigated association
## Abstract The aim of this study was to investigate associations between genetic variability in specific Glutathione __S__โtransferases (__GST__) genes (__GSTM1__, __GSTT1__ and __GSTP1__) and susceptibility to breast cancer. Genotypes of blood specimen DNA were determined for 65 women with incide
## Abstract ## BACKGROUND: Esophageal atresia (EA) is a lifeโthreatening congenital condition whose etiology and pathogenesis are still poorly understood. An increasing trend of this pathology in some Italian regions suggests a possible interaction between xenobiotics and genes involved in detoxif
Glutathione S-transferases (GSTs) are an important part of the protection system against a wide range of potentially harmful chemical compounds. GSTP1 and GSTM1 are mainly involved in detoxification reactions of PAH carcinogenic intermediates produced by cytochrome P450 (CYP). Polymorphism of the GS