Genetic polymorphisms ofGSTO2,GSTM1, andGSTT1and risk of gastric cancer
β Scribed by Mohammad Masoudi; Iraj Saadat; Shahpour Omidvari; Mostafa Saadat
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 176 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0301-4851
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## Abstract Glutathione SβTransferases (GSTs) are a family of phase II enzymes involved in the detoxification of potential carcinogens and provided of a strong antioxidant function by neutralizing electrophiles and free radicals. The __GSTM1__ and __GSTT1__ isoenzymes exhibit deletion polymorphisms
## Abstract Isothiocyanates (ITCs) are nonnutrient compounds in cruciferous vegetables with anticarcinogenic properties. ITCs downβregulate cytochrome Pβ450 biotransformation enzyme levels, activate Phase II detoxifying enzymes and induce apoptosis. On the other hand, ITCs also serve as a substrate