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Genetic polymorphisms of gene conversion within the duplicated human α-globin loci

✍ Scribed by Hitoshi Nakashima; Asao Fujiyama; Shunjiro Kagiyama; Takashi Imamura

Publisher
Springer
Year
1990
Tongue
English
Weight
438 KB
Volume
84
Category
Article
ISSN
0340-6717

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✦ Synopsis

Of the 645 Japanese subjects studied, we have identified 10 individuals heterozygous for a chromosome with the triplicated alpha-globin loci. The frequency of the triple alpha-loci was 0.008 in this population, while that of the single alpha-locus, i.e., alpha-thalassemia 2 gene, might be lower than 0.0008. Analysis of haplotypes using particular RsaI site polymorphism in the alpha-globin gene complex strongly suggests that the triple alpha loci may have had multiple origins in this population.

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