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Amplification of the topoisomerase ii α gene in a non-small cell lung cancer cell line and characterisation of polymorphisms at the human topoisomerase ii α and β loci in normal tissue

✍ Scribed by W. Nicol Keith; Robert Brown; K. B. Tan

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
738 KB
Volume
4
Category
Article
ISSN
1045-2257

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✦ Synopsis

n sylvan la (K. B.T.) DNA was prepared from normal tissue and I9 lung cancer cell lines. Using probes which detect restriction fragment length polymorphisms at both the topoisomerase II u and p loci, heterozygosity was detected at a frequency of 0. I 7 and 0.37 for the

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