## Abstract ## BACKGROUND. Pancreatic cancer is a multifactorial disease with metastasis‐prone and therapy‐resistant nature. The authors hypothesized that genetic variants of glutathione S‐transferase (GST) affect detoxification of carcinogens and anticancer agents in the human pancreas and, thus,
Genetic polymorphism of glutathione S-transferase P1 gene and lung cancer risk
✍ Scribed by Jordi To-Figueras; Manel Gené; Jesús Gómez-catalán; Esther Piqué; Natividad Borrego; Josep Lluís Carrasco; Josep Ramón; Jacint Corbella
- Book ID
- 110268056
- Publisher
- Springer Netherlands
- Year
- 1999
- Tongue
- English
- Weight
- 94 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0957-5243
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Glutathione S-transferases (GSTs) belong to a superfamily of detoxification enzymes that provide critical defences against a large variety of chemical carcinogens and environmental toxicants. GSTs are present in most epithelial tissues of the human gastrointestinal tract. We investigated association
## Abstract ## Background. Factors determining the individual susceptibility to head and neck squamous cell carcinoma (HNSCC) are still largely unknown. An imbalance between enzymes involved in the toxification and detoxification of (pre)‐carcinogens closely related to HNSCC, which may appear duri