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Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients withHelicobacter pyloriinfection

✍ Scribed by Ghoshal, Ujjala; Tripathi, Shweta; Kumar, Sushil; Mittal, Balraj; Chourasia, Dipti; Kumari, Niraj; Krishnani, Narendra; Ghoshal, Uday C.


Book ID
120359364
Publisher
Springer
Year
2013
Tongue
English
Weight
293 KB
Volume
17
Category
Article
ISSN
1436-3291

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## Abstract Cytochrome P450 (CYP) 2A6 and __CYP2E1__ are enzymes with a high ability to activate a nitrosamine, 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK), to its potent and ultimate carcinogens. The polymorphic __CYP2A6__ and __CYP2E1__ have been implicated in increased susceptibility to