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Alcohol withdrawal investigation of Cytochrome P450 CYP1A2, CYP2D6, CYP2E1 and CYP3A4 expression and gene polymorphism

✍ Scribed by Nazife Tascioglu; Cetin Saatci; Ertugrul Esel; Munis Dundar


Book ID
118473968
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
64 KB
Volume
161
Category
Article
ISSN
0168-1656

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## Abstract Cytochrome P450 (CYP) 2A6 and __CYP2E1__ are enzymes with a high ability to activate a nitrosamine, 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK), to its potent and ultimate carcinogens. The polymorphic __CYP2A6__ and __CYP2E1__ have been implicated in increased susceptibility to