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Cytochrome P450 (CYP) 1A2, sulfotransferase (SULT) 1A1, and N-acetyltransferase (NAT) 2 polymorphisms and susceptibility to urothelial cancer

✍ Scribed by Hiromasa Tsukino; Yoshiki Kuroda; Hiroyuki Nakao; Hirohisa Imai; Hisato Inatomi; Yukio Osada; Takahiko Katoh


Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
202 KB
Volume
130
Category
Article
ISSN
1432-1335

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Carcinogenic aromatic amines such as 4-aminobiphenyl, which is contained in tobacco smoke, are one of the causal factors of urothelial epithelial cancers. 4-Aminobiphenyl has been shown to be bioactivated through N-hydroxylation by hepatic cytochrome (CYP) 1A2 and subsequently through O-sulfation an

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