Cytochrome P450 (CYP) 1A2, sulfotransferase (SULT) 1A1, and N-acetyltransferase (NAT) 2 polymorphisms and susceptibility to urothelial cancer
β Scribed by Hiromasa Tsukino; Yoshiki Kuroda; Hiroyuki Nakao; Hirohisa Imai; Hisato Inatomi; Yukio Osada; Takahiko Katoh
- Publisher
- Springer-Verlag
- Year
- 2004
- Tongue
- English
- Weight
- 202 KB
- Volume
- 130
- Category
- Article
- ISSN
- 1432-1335
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Carcinogenic aromatic amines such as 4-aminobiphenyl, which is contained in tobacco smoke, are one of the causal factors of urothelial epithelial cancers. 4-Aminobiphenyl has been shown to be bioactivated through N-hydroxylation by hepatic cytochrome (CYP) 1A2 and subsequently through O-sulfation an
The polymorphic arylamine N-acetyltransferases (NAT1 and NAT2) have been implicated in increased susceptibility to certain malignancies. We analyzed genetic polymorphisms in both the NAT1 and NAT2 genes among 140 gastric adenocarcinoma patients, 103 colorectal adenocarcinoma patients and 122 healthy