Genetic linkage and psychiatric disease
โ Scribed by GURLING, HUGH
- Book ID
- 109763000
- Publisher
- Nature Publishing Group
- Year
- 1990
- Tongue
- English
- Weight
- 141 KB
- Volume
- 344
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/344298a0
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Results from the study by Sherrington et a]. [1988] indicate that the maximum lod score (3.2) from a linkage analysis between narrowly defined clinical diagnostic criteria for schizophrenia and polymorphic markers on chromosome 5 is lower than that (6.5) from an analogous analysis between broadly de
For diseases with a complex mode of inheritance, such as schizophrenia, traditional linkage analysis assuming Mendelian inheritance of a single gene may be expected to have relatively low power, but to occasionally detect (in fortuitous pedigree samples) either a rare gene which by itself causes the
I should like to make four points in connection with Neil Risch's [ 19901 provocative and thoughtful review.