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Genetic linkage and psychiatric disease

โœ Scribed by GURLING, HUGH


Book ID
109763000
Publisher
Nature Publishing Group
Year
1990
Tongue
English
Weight
141 KB
Volume
344
Category
Article
ISSN
0028-0836

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Results from the study by Sherrington et a]. [1988] indicate that the maximum lod score (3.2) from a linkage analysis between narrowly defined clinical diagnostic criteria for schizophrenia and polymorphic markers on chromosome 5 is lower than that (6.5) from an analogous analysis between broadly de

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For diseases with a complex mode of inheritance, such as schizophrenia, traditional linkage analysis assuming Mendelian inheritance of a single gene may be expected to have relatively low power, but to occasionally detect (in fortuitous pedigree samples) either a rare gene which by itself causes the

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I should like to make four points in connection with Neil Risch's [ 19901 provocative and thoughtful review.