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Genetic linkage and complex diseases: A comment

✍ Scribed by Elliot S. Gershon

Book ID: 102225571
Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 229 KB
Volume: 7
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370070105

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📜 SIMILAR VOLUMES

Genetic linkage and complex diseases: A

Genetic linkage and complex diseases: A comment

✍ R. C. Elston; A. F. Wilson 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 191 KB

Results from the study by Sherrington et a]. [1988] indicate that the maximum lod score (3.2) from a linkage analysis between narrowly defined clinical diagnostic criteria for schizophrenia and polymorphic markers on chromosome 5 is lower than that (6.5) from an analogous analysis between broadly de

Genetic linkage and complex diseases: A

Genetic linkage and complex diseases: A comment

✍ Philip Green 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 211 KB

For diseases with a complex mode of inheritance, such as schizophrenia, traditional linkage analysis assuming Mendelian inheritance of a single gene may be expected to have relatively low power, but to occasionally detect (in fortuitous pedigree samples) either a rare gene which by itself causes the

Genetic linkage and complex diseases: A

Genetic linkage and complex diseases: A comment

✍ Steven Matthysse 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 176 KB

I should like to make four points in connection with Neil Risch's [ 19901 provocative and thoughtful review.

Genetic linkage and complex diseases: A

Genetic linkage and complex diseases: A comment

✍ Newton E. Morton 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 140 KB

A linkage test in complex disease is well motivated under either of two conditions: if a prior segregation analysis has given evidence for a major gene, or if there is a candidate locus that may influence liability. Although methods have been developed for pairs of affected relatives without specify

Genetic linkage and complex diseases: A

Genetic linkage and complex diseases: A comment

✍ Jurg Ott 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 143 KB

Dr. Risch [ 19901 is to be commended for his authoritative investigation and review of the many potential problems associated with linkage analysis of complex diseases. Such a comprehensive report has long been due. Here, I would like to expand on a technique briefly referred to towards the end of t

Genetic linkage and complex diseases: A

Genetic linkage and complex diseases: A comment

✍ Brian K. Suarez; Theodore Reich; John P. Rice; C. Robert Cloninger 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 263 KB

Thefirst thing to do in the study of human heredity is tofind characters which vary sharply so as to divide mankind definitely into classes. . . . Now i f we had about fifty such characters . . . we could use them . . .for the study of such characters as musical ability, obesity and bad temper. When