๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Genetic linkage and complex diseases: A comment

โœ Scribed by Brian K. Suarez; Theodore Reich; John P. Rice; C. Robert Cloninger

Book ID
102225576
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
263 KB
Volume
7
Category
Article
ISSN
0741-0395

No coin nor oath required. For personal study only.

โœฆ Synopsis

Thefirst thing to do in the study of human heredity is tofind characters which vary sharply so as to divide mankind definitely into classes. . . . Now i f we had about fifty such characters . . . we could use them . . .for the study of such characters as musical ability, obesity and bad temper. When a baby arrived we should have a physical examination and a blood analysis done on him and say something like this: "He has got iso-agglutinin B and tyrosinase inhibitor J from his father, so it's twenty to one that he will get the main gene that determined his father's mathematical powers: but he's got Q4 from his mother . . . so it looks as if her father's inability to keep away from alcohol would crop up in him. . . .

๐Ÿ“œ SIMILAR VOLUMES

Genetic linkage and complex diseases: A
Genetic linkage and complex diseases: A comment
โœ R. C. Elston; A. F. Wilson ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 191 KB

Results from the study by Sherrington et a]. [1988] indicate that the maximum lod score (3.2) from a linkage analysis between narrowly defined clinical diagnostic criteria for schizophrenia and polymorphic markers on chromosome 5 is lower than that (6.5) from an analogous analysis between broadly de

Genetic linkage and complex diseases: A
Genetic linkage and complex diseases: A comment
โœ Philip Green ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 211 KB

For diseases with a complex mode of inheritance, such as schizophrenia, traditional linkage analysis assuming Mendelian inheritance of a single gene may be expected to have relatively low power, but to occasionally detect (in fortuitous pedigree samples) either a rare gene which by itself causes the

Genetic linkage and complex diseases: A
Genetic linkage and complex diseases: A comment
โœ Steven Matthysse ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 176 KB

I should like to make four points in connection with Neil Risch's [ 19901 provocative and thoughtful review.

Genetic linkage and complex diseases: A
Genetic linkage and complex diseases: A comment
โœ Newton E. Morton ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 140 KB

A linkage test in complex disease is well motivated under either of two conditions: if a prior segregation analysis has given evidence for a major gene, or if there is a candidate locus that may influence liability. Although methods have been developed for pairs of affected relatives without specify

Genetic linkage and complex diseases: A
Genetic linkage and complex diseases: A comment
โœ Jurg Ott ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 143 KB

Dr. Risch [ 19901 is to be commended for his authoritative investigation and review of the many potential problems associated with linkage analysis of complex diseases. Such a comprehensive report has long been due. Here, I would like to expand on a technique briefly referred to towards the end of t