Genetic heterogeneity in supratentorial and infratentorial primitive neuroectodermal tumours of the central nervous system
✍ Scribed by M M Inda; C Perot; M Guillaud-Bataille; G Danglot; J A Rey; M J Bello; X Fan; C Eberhart; I Zazpe; E Portillo; T Tuñón; J M Martínez-Peñuela; A Bernheim; J S Castresana
- Book ID
- 108780040
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 284 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0309-0167
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Deletion of 17p is the most frequent abnormality observed in central nervous system (CNS) primitive neuroectodermal tumors (PNETs), implicating the presence of a tumor suppressor gene which maps to 17p. The gene for pigment epitheliumderived factor (PEDF) has been cloned and mapped to 17p13. PEDF be
## Abstract Supratentorial primitive neuroectodermal tumors (stPNETs) and medulloblastomas have long been thought to arise from a common cell type in the subventricular germinal matrix. Because of the infrequent occurrence of stPNETs, little is known about their genetic background. Here, we perform