## Abstract We previously reported an i(17q) as a nonβrandom finding in childhood primitive neuroectodermal tumors (PNETs) of the central nervous system. In the present study, we describe a twoβcolor interphase fluorescence in situ hybridization (FISH) assay for detection of chromosome 17 abnormali
Isochromosome 17q in primitive neuroectodermal tumors of the central nervous system
β Scribed by Dr. Jaclyn A. Biegel; Lucy B. Rorke; Roger J. Packer; Leslie N. Sutton; Luis Schut; Kathy Bonner; Beverly S. Emanuel
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 705 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1045-2257
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We have shown that an i(17q) is the most frequent abnormality in central nervous system primitive neuroectodermal tumors (PNETs; medulloblastoma), implicating the presence of a tumor suppressor gene which maps to 17p. In the present study, we investigated whether the deletion of chromosome arm 17p t
Deletion of 17p is the most frequent abnormality observed in central nervous system (CNS) primitive neuroectodermal tumors (PNETs), implicating the presence of a tumor suppressor gene which maps to 17p. The gene for pigment epitheliumderived factor (PEDF) has been cloned and mapped to 17p13. PEDF be
## Abstract ## BACKGROUND Radiation induced intracranial neoplasms are uncommon but well described and include gliomas, meningiomas, and sarcomas. The development of primitive neuroectodermal tumors (PNETs) following prophylactic craniospinal irradiation has been infrequently reported previously.