RASSF1A promoter is highly methylated in primitive neuroectodermal tumors of the central nervous system
✍ Scribed by María-del-Mar Inda; Javier S Castresana
- Book ID
- 108957935
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 93 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0919-6544
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📜 SIMILAR VOLUMES
## Abstract ## BACKGROUND Radiation induced intracranial neoplasms are uncommon but well described and include gliomas, meningiomas, and sarcomas. The development of primitive neuroectodermal tumors (PNETs) following prophylactic craniospinal irradiation has been infrequently reported previously.
Deletion of 17p is the most frequent abnormality observed in central nervous system (CNS) primitive neuroectodermal tumors (PNETs), implicating the presence of a tumor suppressor gene which maps to 17p. The gene for pigment epitheliumderived factor (PEDF) has been cloned and mapped to 17p13. PEDF be